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    • Identification of two genes potentially associated in iron-heme homeostasis in human carotid plaque using microarray analysis

      Hanène Ayari Giampiero Bricca

      Articles Volume 38 Issue 2 June 2013 pp 311-315

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/038/02/0311-0315

    • Keywords

       

      Human carotid plaque; iron-heme homeostasis; microarray

    • Abstract

       

      Classic characteristics are poor predictors of the risk of thromboembolism. Thus, better markers for the carotid atheroma plaque formation and symptom causing are needed. Our objective was to study by microarray analysis gene expression of genes involved in homeostasis of iron and heme in carotid atheroma plaque from the same patient. mRNA gene expression was measured by an Affymetrix GeneChip Human Gene 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RNA prepared from 68 specimens of endarteriectomy from 34 patients. Two genes involved in iron-heme homeostasis, CD163 and heme oxygenase (HO-1), were analysed in 34 plaques. CD163 (2.18, 𝑝=1.45E−08) and HO-1 (fold-change 2.67, 𝑝=2.07E−09) mRNAs were induced. We suggest that atheroma plaques show a more pronounced induction of CD163 and HO-1. Although further evidence is needed, our results support previous data. To our knowledge, this is the first report comparing gene expression between intact arterial tissue and carotid plaque using microarray analysis.

    • Author Affiliations

       

      Hanène Ayari1 Giampiero Bricca1

      1. Université Lyon1, INSERM, ERI22, EA 4173, Lyon, France

    • Dates

       
      Published
      June 2013
      Manuscript received
      29 June 2012
      Accepted
      12 February 2013

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