1. Home
    2. Journals
    3. Journal of Biosciences
    4. Volume 37
    5. Issue 6

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/037/06/0953-0963

    • Keywords

       

      Molecular crowding; molecular plasticity; molecular shape; peptidyl-tRNA hydrolase; protein function

    • Abstract

       

      The discrepancy between the X-ray and NMR structures of Mycobacterium tuberculosis peptidyl-tRNA hydrolase in relation to the functionally important plasticity of the molecule led to molecular dynamics simulations. The X-ray and the NMR studies along with the simulations indicated an inverse correlation between crowding and molecular volume. A detailed comparison of proteins for which X-ray and the NMR structures appears to confirm this correlation. In consonance with the reported results of the investigations in cellular compartments and aqueous solution, the comparison indicates that the crowding results in compaction of the molecule as well as change in its shape, which could specifically involve regions of the molecule important in function. Crowding could thus influence the action of proteins through modulation of the functionally important plasticity of the molecule.

    • Author Affiliations

       

      M Selvaraj1 Rais Ahmad2 Umesh Varshney2 M Vijayan1

      1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012
      2. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012

    • Dates

       
      Published
      December 2012
      Manuscript received
      16 July 2012
      Accepted
      7 October 2012

    • Supplementary Material

       

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
      <

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2023-2024 Indian Academy of Sciences, Bengaluru.

Contact | Site index