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      https://www.ias.ac.in/article/fulltext/jbsc/037/05/0911-0919

    • Keywords

       

      Haplogroup; migration; mitochondrial DNA; population; Y-chromosome

    • Abstract

       

      Indian populations are classified into various caste, tribe and religious groups, which altogether makes them very unique compared to rest of the world. The long-term firm socio-religious boundaries and the strict endogamy practices along with the evolutionary forces have further supplemented the existing high-level diversity. As a result, drawing definite conclusions on its overall origin, affinity, health and disease conditions become even more sophisticated than was thought earlier. In spite of these challenges, researchers have undertaken tireless and extensive investigations using various genetic markers to estimate genetic variation and its implication in health and diseases. We have demonstrated that the Indian populations are the descendents of the very first modern humans, who ventured the journey of out-of-Africa about 65,000 years ago. The recent gene flow from east and west Eurasia is also evident. Thus, this review attempts to summarize the unique genetic variation among Indian populations as evident from our extensive study among approximately 20,000 samples across India.

    • Author Affiliations

       

      Rakesh Tamang1 Lalji Singh1 2 3 Kumarasamy Thangaraj1

      1. CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007
      2. Genome Foundation, Hyderabad 500 007
      3. Banaras Hindu University, Varanasi 221 005
    • Dates

       
  • Journal of Biosciences | News

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