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    • Keywords


      Exogenous stress; in vivo NMR; metabolomic; Saccharomyces cerevisiae; STOCSY

    • Abstract


      In vivo NMR spectroscopy, together with selectively 13C-labelled substrates and ‘statistical total correlation spectroscopy’ analysis (STOCSY), are valuable tools to collect and interpret the metabolic responses of a living organism to external stimuli. In this study, we applied this approach to evaluate the effects of increasing concentration of exogenous ethanol on the Saccharomyces cerevisiae fermentative metabolism. We show that the STOCSY analysis correctly identifies the different types of correlations among the enriched metabolites involved in the fermentation, and that these correlations are quite stable even in presence of a stressing factor such as the exogenous ethanol.

    • Author Affiliations


      Maso Ricci1 2 Marianna Aggravi1 Claudia Bonechi1 Silvia Martini1 Anna Maria1 Claudio Rossi1 3

      1. Department of Pharmaceutical and Applied Chemistry, University of Siena, Siena, Italy and Center for Colloid and Surface Science (CSGI), Via della Lastruccia 3, Sesto Fiorentino, FI, Italy
      2. San Carlo Clinic, Via dell'Ospedale 21, 20037 Paderno Dugnano (MI), Italy
      3. Pain and Stress Neurophysiology Lab, Department of Physiology, University of Siena, Siena, Italy
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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