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      https://www.ias.ac.in/article/fulltext/jbsc/037/03/0475-0481

    • Keywords

       

      Dual mode of binding; intercalators; groove binders; single mode of binding; transcription inhibitors

    • Abstract

       

      One class of small molecules with therapeutic potential for treatment of cancer functions as transcription inhibitors via interaction with double-stranded DNA. Majority of the studies of the interaction with DNA have so far been reported under conditions nonexistent in vivo. Inside the cell, DNA is present in the nucleus as a complex with proteins known as chromatin. For the last few years we have been studying the interaction of these DNA-binding small molecules at the chromatin level with emphasis on the drug-induced structural alterations in chromatin. Our studies have shown that at the chromatin level these molecules could be classified in two broad categories: single-binding and dual-binding molecules. Single-binding molecules access only DNA in the chromatin, while the dual-binding molecules could bind to both DNA and the associated histone(s). Structural effects of the DNA-binding molecules upon chromatin in light of the above broad categories and the associated biological implications of the two types of binding are discussed.

    • Author Affiliations

       

      Dipak Dasgupta1 Parijat Majumder1 Amrita Banerjee1

      1. Biophysics Division, Saha Institute of Nuclear Physics, Bidhan Nagar, Kolkata 700 064, India
    • Dates

       
  • Journal of Biosciences | News

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