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    • Keywords


      Asthma; free radical; IgE; phlorotannins; Polyopes affinis

    • Abstract


      Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this study was to determine whether an ethanol extract of Polyopes affinis (P.affinis) can inhibit the pathogenesis of T helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergen-specific immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic disorders such as allergic asthma.

    • Author Affiliations


      Dae-Sung Lee1 Won Sun Park2 Soo-Jin Heo3 Seon-Heui Cha4 Daekyung Kim4 You-Jin Jeon5 Sae-Gwang Park6 Su-Kil Seo6 Jung Sik Choi7 Sung-Jae Park7 Eun Bo Shim8 Il-Whan Choi6 Won-Kyo Jung9

      1. POSTECH Ocean Science and Technology Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea
      2. Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200-701, Republic of Korea
      3. Marine Living Resources Research Department, Korea Ocean Research and Development Institute, Ansan 426-744, Republic of Korea
      4. Marine Bio Research Team, Korea Basic Science Institute, Jeju 690-756, Republic of Korea
      5. Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, Republic of Korea
      6. Department of Microbiology, College of Medicine and Advanced Research Center for Multiple Myeloma, Inje University, Busan 614-735, Republic of Korea
      7. Department of Internal Medicine, College of Medicine and Advanced Research Center for Multiple Myeloma, Inje University, Busan 614-735, Republic of Korea
      8. Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 200-701, Republic of Korea
      9. Department of Marine Life Science, Chosun University, Gwangju 501-759, Republic of Korea
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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