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    • Keywords


      DNA repair; heterochromatin; lamin; nuclear envelope; proteasome; ubiquitin ligases

    • Abstract


      Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.

    • Author Affiliations


      Veena K Parnaik1 Pankaj Chaturvedi1 B H Muralikrishna1

      1. Centre for Cellular and Molecular Biology (CSIR), Hyderabad 500 007, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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