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      https://www.ias.ac.in/article/fulltext/jbsc/036/02/0383-0396

    • Keywords

       

      Alloxan diabetes; metabolic pathways; sodium orthovanadate; trace metals; Trigonella foenum-graecum seed powder

    • Abstract

       

      Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycaemia resulting in defective insulin secretion, resistance to insulin action or both. The use of biguanides, sulphonylurea and other drugs are valuable in the treatment of diabetes mellitus; their use, however, is restricted by their limited action, pharmaco-kinetic properties, secondary failure rates and side effects. Trigonella foenum-graecum, commonly known as fenugreek, is a plant that has been extensively used as a source of antidiabetic compounds from its seeds and leaf extracts. Preliminary human trials and animal experiments suggest possible hypoglycaemic and anti-hyperlipedemic properties of fenugreek seed powder taken orally. Our results show that the action of fenugreek in lowering blood glucose levels is almost comparable to the effect of insulin. Combination with trace metal showed that vanadium had additive effects and manganese had additive effects with insulin on in vitro system in control and diabetic animals of young and old ages using adipose tissue. The Trigonella and vanadium effects were studied in a number of tissues including liver, kidney, brain peripheral nerve, heart, red blood cells and skeletal muscle. Addition of Trigonella to vanadium significantly removed the toxicity of vanadium when used to reduce blood glucose levels. Administration of the various combinations of the antidiabetic compounds to diabetic animals was found to reverse most of the diabetic effects studied at physiological, biochemical, histochemical and molecular levels. Results of the key enzymes of metabolic pathways have been summarized together with glucose transporter, Glut-4 and insulin levels. Our findings illustrate and elucidate the antidiabetic/insulin mimetic effects of Trigonella, manganese and vanadium.

    • Author Affiliations

       

      Najma Zaheer Baquer1 Pardeep Kumar1 Asia Taha1 R K Kale1 S M Cowsik1 P McLean2

      1. School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
      2. Division of Biosciences, Faculty of Life Sciences, University College London, WC1E 6BT, London, UK
    • Dates

       
  • Journal of Biosciences | News

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