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    • Keywords


      Ethanol yield; in vivo NMR; iron metabolism; mathematical modelling; oxidative stress; Saccharomyces cerevisiae

    • Abstract


      Mathematical modelling analysis of experimental data, obtained with in vivo NMR spectroscopy and 13C-labelled substrates, allowed us to describe how the fermentative metabolism in Saccharomyces cerevisiae, taken as eukaryotic cell model, is influenced by stress factors. Experiments on cellular cultures subject to increasing concentrations of ferric ions were conducted in order to study the effect of oxidative stress on the dynamics of the fermentative process. The developed mathematical model was able to simulate the cellular activity, the metabolic yield and the main metabolic fluxes occurring during fermentation and to describe how these are modulated by the presence of ferric ions.

    • Author Affiliations


      Maso Ricci1 2 Silvia Martini1 2 Claudia Bonechi1 2 Daniela Braconi3 Annalisa Santucci3 Claudio Rossi1 2

      1. Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro, 2–53100 Siena, Italy
      2. Center for Colloid and Surface Science (CSGI), Via della Lastruccia 3, Sesto Fiorentino, FI, Italy
      3. Department of Molecular Biology, Università di Siena, Via Fiorentina, 1–53100 Siena, Italy
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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