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    • Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. leaves

      S Ignacimuthu N Shanmugam

      Articles Volume 35 Issue 4 December 2010 pp 565-570

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/035/04/0565-0570

    • Keywords

       

      2-acetyl benzylamine; Adhatoda vasica; antimycobacterial activity; Mycobacterium tuberculosis; vasicine acetate

    • Abstract

       

      In folk medicine, Adhatoda vasica Ness. (Acanthaceae) is used to treat asthma and cough. The leaves of A.vasica were powdered and extracted with hexane, ethyl acetate and methanol. The hexane extract showed 97% reduction in colony-forming units (CFU) at 100 𝜇g/ml. The hexane extract was subjected to column chromatography. Two natural compounds, vasicine acetate and 2-acetyl benzylamine, were isolated from it. They were bioassayed against Mycobacterium tuberculosis. The two compounds showed strong antimycobacterial activity. Vasicine acetate and 2-acetyl benzylamine isolated from hexane extract of A. vasica leaves, significantly inhibited M. tuberculosis and one multi-drug-resistant (MDR) strain and one sensitive strain at 200 and 50 𝜇g/ml, respectively. Our study demonstrated that both the compounds, vasicine acetate and 2-acetyl benzylamine, could be evaluated further for developing a drug to control M. tuberculosis.

    • Author Affiliations

       

      S Ignacimuthu1 N Shanmugam1

      1. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India

    • Dates

       
      Published
      December 2010
      Manuscript received
      18 December 2009
      Accepted
      21 September 2010
      Early published
      19 October 2010

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