• Antibacterial abietane-type diterpenoid, taxodone from Metasequoia glyptostroboides Miki ex Hu

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    • Keywords

       

      Antibacterial activity; diterpenoid; foodborne pathogens; Metasequoia glyptostroboides; taxodone

    • Abstract

       

      In an attempt to isolate bioactive constituents, ethyl acetate cone extract of Metasequoia glyptostroboides was subjected to a column chromatographic analysis that resulted in isolation of an abietane-type diterpenoid, taxodone. Its structure was elucidated by spectroscopic means. Further, taxodone showed potential antibacterial effect as diameters of zones of inhibition against foodborne pathogenic bacteria, such as Listeria monocytogenes ATCC 19166, Salmonella typhimurium KCTC 2515, S. enteritidis KCTC 2021, Escherichia coli ATCC 8739, E. coli O157:H7 ATCC 43888, Enterobacter aerogenes KCTC 2190, Staphylococcus aureus ATCC 6538 and S. aureus KCTC 1916, were found in the range of 9.4 to 14.2 mm. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of taxodone against the employed bacterial pathogens were found in the range of 250 to 1000 and 250 to < 2000 𝜇g/ml, respectively. Also the compound had a strong antibacterial effect on the viable counts of the tested bacteria. These findings indicate that the bioactive compound taxodone present in M. glyptostroboides could be used as an antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens.

    • Author Affiliations

       

      Vivek K Bajpai1 Sun Chul Kang1

      1. Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea
    • Dates

       
  • Journal of Biosciences | News

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