• Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      Acid resistance; bacterial patrogenesis; structural genomics

    • Abstract


      The urease of the human pathogen, Helicobacter pylori, is essential for pathogenesis. The ammonia produced by the enzyme neutralizes stomach acid; thereby modifying its environment. The dodecameric enzyme complex has high affinity for its substrate, urea. We compared urease sequences and derivative 3D homology model structures from all published Helicobacter genomes and an equal number of genomes belonging to strains of another enteric bacterium, Escherichia coli. We found that the enzyme’s architecture adapts to fit its niche. This finding, coupled to a survey of other physiological features responsible for the bacterium’s acid resistance, suggests how it copes with pH changes caused by disease onset and progression.

    • Author Affiliations


      Shahid Khan1 2 Asim Karim1 Shaheryar Iqbal1

      1. Departments of Lifesciences and # Computer Science, School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Punjab, Pakistan
      2. Molecular Biology Consortium, Chicago, IL 60612, USA
    • Dates

  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.