• Quantitative effect and regulatory function of cyclic adenosine 5'-phosphate in Escherichia coli

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    • Keywords


      CRP–cAMP; regulation; repression

    • Abstract


      Cyclic adenosine 5′-phosphate (cAMP) is a global regulator of gene expression in Escherichia coli. Despite decades of intensive study, the quantitative effect and regulatory function of cAMP remain the subjects of considerable debate. Here, we analyse the data in the literature to show that:


      In carbon-limited cultures, growth is limited by the supply of energy; the cAMP levels therefore increase to enhance energy accumulation by activating the catabolic promoters and inhibiting the anabolic promoters. Conversely, in carbon-excess cultures, characterized by the availability of excess energy, the cAMP levels decrease in order to depress energy accumulation by inhibiting the catabolic promoters and activating the anabolic promoters.

    • Author Affiliations


      Atul Narang1

      1. Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi 110 016, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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