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    • Keywords


      C1431T; India; metabolic syndrome; Pro12Ala; resistin

    • Abstract


      Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR𝛾 with diabetes and obesity have revealed extensive population-dependent variations. However, association of these polymorphisms with the metabolic syndrome and its individual components has not been well investigated in the Indian population. The Indian population harbours the maximum number of diabetics in the world who are thus more susceptible to metabolic disorders. We screened a South Indian population (𝑁 = 699) for a possible association of these polymorphisms with the metabolic syndrome (MS) and type 2 diabetes. We also investigated the correlation of these two single-nucleotide polymorphisms (SNPs) with plasma resistin levels. The C1431T SNP was associated with higher levels of plasma resistin (𝑃 = 0.017). Furthermore, C1431T was associated with resistin in different tertiles. Prevalence of the ‘Pro-C’ haplotype decreased with increasing tertiles of resistin (84.1% to 75.4%, 𝑃 = 0.037). Plasma resistin levels were not found to be associated with MS and type 2 diabetes. These results point to a likely association of plasma resistin levels with PPAR𝛾 polymorphisms in the Indian population.

    • Author Affiliations


      Abdul Haseeb1 Mohammad Iliyas1 Subhabrata Chakrabarti2 Arif A Farooqui3 Sudhir R Naik3 Sudip Ghosh1 Madhuri Suragani1 Nasreen Z Ehtesham1

      1. Molecular Biology Unit, National Institute of Nutrition, Jamai Osmania, Hyderabad 500 604, India
      2. L V Prasad Eye Institute, Banjara Hills, Hyderabad 500 034, India
      3. Mediciti Hospital, Hyderabad 500 063, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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