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    • Keywords


      Oxygenated bisabolane-type sesquiterpenes (HOBS); proliferation; redifferentiation; tumour

    • Abstract


      Bisabolane-type sesquiterpenes are a class of biologically active compounds that has antitumour, antifungal, antibacterial, antioxidant and antivenom properties. We investigated the effect of two new highly oxygenated bisabolane-type sesquiterpenes (HOBS) isolated from Cremanthodium discoideum (C. discoideum) on tumour cells. Our results showed that HOBS induced morphological differentiation and reduced microvilli formation on the cell surface in SMMC-7721 cells. Flow cytometry analysis demonstrated that HOBS could induce cell-cycle arrest in the G1 phase. Moreover, HOBS was able to increase tyrosine-𝛼-ketoglutarate transaminase activity, decrease 𝛼-foetoprotein level and 𝛾-glutamyl transferase activity. In addition, we found that HOBS inhibited the anchorage-independent growth of SMMC-7721 cells in a dose-dependent manner. Taken together, all the above observations indicate that HOBS might be able to normalize malignant SMMC-7721 cells by inhibiting cell proliferation and inducing redifferentiation.

    • Author Affiliations


      Ruidong Miao1 Juan Wei1 Q I Zhang1 Venkateswara Sajja2 Jinbo Yang1 2 Qin Wang1

      1. School of Life Sciences, Lanzhou University, Lanzhou 730000, P R China
      2. Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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