• Computational methods to dissect cis-regulatory transcriptional networks

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      https://www.ias.ac.in/article/fulltext/jbsc/032/07/1325-1330

    • Keywords

       

      Bioinformatics; cis-regulatory elements; computational methods; nucleic acid-binding protein (NBP); promoter; transcription factor (TF); transcription factor binding sites (TFBS)

    • Abstract

       

      The formation of diverse cell types from an invariant set of genes is governed by biochemical and molecular processes that regulate gene activity. A complete understanding of the regulatory mechanisms of gene expression is the major function of genomics. Computational genomics is a rapidly emerging area for deciphering the regulation of metazoan genes as well as interpreting the results of high-throughput screening. The integration of computer science with biology has expedited molecular modelling and processing of large-scale data inputs such as microarrays, analysis of genomes, transcriptomes and proteomes. Many bioinformaticians have developed various algorithms for predicting transcriptional regulatory mechanisms from the sequence, gene expression and interaction data. This review contains compiled information of various computational methods adopted to dissect gene expression pathways.

    • Author Affiliations

       

      Vibha Rani1

      1. Department of Biotechnology, Jaypee Institute of Information Technology University, A-10, Sector 62, Noida 210 307, India
    • Dates

       
  • Journal of Biosciences | News

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