• Modularized study of human calcium signalling pathway

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      https://www.ias.ac.in/article/fulltext/jbsc/032/05/1009-1017

    • Keywords

       

      Biological networks; network modularization; nucleoplasmic reticulum; signal transduction

    • Abstract

       

      Signalling pathways are complex biochemical networks responsible for reg ulation of numerous cellular functions. These networks function by serial and successive interactions among a large number of vital biomolecules and chemical compounds. For deciphering and analysing the underlying mechanism of such networks, a modularized study is quite helpful. Here we propose an algorithm for modularization of calcium signalling pathway of H. sapiens. The idea that ``a node whose function is dependant on maximum number of other nodes tends to be the center of a sub network” is used to divide a large signalling network into smaller sub networks. Inclusion of node(s) into sub networks(s) is dependant on the outdegree of the node(s). Here outdegree of a node refers to the number of re lations of the considered node lying outside the constructed sub network. Node(s) having more than c relations lying outside the expanding subnetwork have to be excluded from it. Here 𝑐 is a specified variable based on user preference, which is finally fixed during adjustments of created subnetworks, so that certain biological significance can be conferred on them.

    • Author Affiliations

       

      Losiana Nayak1 Rajat K De1

      1. Machine Intelligence Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata 700 108, India
    • Dates

       
  • Journal of Biosciences | News

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