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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/032/05/0999-1004

    • Keywords

       

      Functional site prediction; phylogenetic motif; sequence-function relationship

    • Abstract

       

      Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor. Occurrence of proline was very high for calpain 10 gene and glucose transporter

    • Author Affiliations

       

      Ashok Sharma1 Tanuja Rastogi1 Meenakshi Bhartiya1 A K Shasany1 S P S Khanuja1

      1. Bioinformatics Division, Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India
    • Dates

       
  • Journal of Biosciences | News

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