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    • Keywords


      Selenium; ER stress; insulin signal; NOD; lipid metabolism; apoptosis

    • Abstract


      To investigate whether selenium (Sel) treatment would impact on the onset of diabetes, we examined serum biochemical components including glucose and insulin, endoplasmic reticulum (ER) stress and insulin signalling proteins, hepatic C/EBP-homologous protein (CHOP) expression and DNA fragmentation in diabetic and non-diabetic conditions of non-obese diabetic (NOD) mice. We conclude that

      1. Sel treatment induced insulin-like effects in lowering serum glucose level in Sel-treated NOD mice,

      2. Sel-treated mice had significantly decreased serum biochemical components associated with liver damage and lipid metabolism,

      3. Sel treatment led to the activation of the ER stress signal through the phosphorylation of JNK and eIF2 protein and insulin signal mechanisms through the phosphorylation of Akt and PI3 kinase, and

      4. Sel-treated mice were significantly relieved apoptosis of liver tissues indicated by DNA fragmentation assay in the diabetic NOD group.

      These results suggest that Sel compounds not only serve as insulin-like molecules for the downregulation of glucose level and the incidence of liver damage, but may also have the potential for the development of new drugs for the relief of diabetes by activating the ER stress and insulin signalling pathways.

    • Author Affiliations


      Daeyoun Hwang1 Sujin Seo1 Yongkyu Kim1 Chuelkyu Kim1 Sunbo Shim1 Seungwan Jee1 Suhae Lee1 Mikyong Jang1 Minsun Kim1 Suyoun Yim1 Sang-Koo Lee2 Byeongcheol Kang3 Insurk Jang4 Jungsik Cho1

      1. Laboratory Animal Resources Team, National Institute of Toxicological Research, Korea FDA, Seoul 122-704, Korea
      2. Center for Laboratory Animal Science, Hanyang University College of Medicine, 133-791, Korea
      3. Department of Experimental Animal Research, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
      4. Department of Animal Science and Biotechnology, RAIC, Jinju National University, Jinju 660-758, Korea
    • Dates

  • Journal of Biosciences | News

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