• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/032/02/0405-0413

    • Keywords

       

      Fatty acid; insulin receptor; insulin resistance, insulin signalling; novel PKC; type 2 diabetes

    • Abstract

       

      Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCε causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.

    • Author Affiliations

       

      Samir Bhattacharya1 Debleena Dey2 Sib Sankar Roy2

      1. Cellular and Molecular Endocrinology Laboratory, Department of Zoology, School of Life Science, Visva-Bharati (A Central University), Santiniketan 731 235, India
      2. Molecular Endocrinology Laboratory, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    • Dates

       
  • Journal of Biosciences | News

© 2017-2019 Indian Academy of Sciences, Bengaluru.