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    • Translesion DNA polymerases Pol ζ, Pol η, Pol ι, Pol κ and Rev1 are not essential for repeat-induced point mutation inNeurospora crassa

      Ranjan Tamuli C Ravindran Durgadas P Kasbekar

      Volume 31 Issue 5 December 2006 pp 557-564

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/031/05/0557-0564

    • Keywords

       

      Mutagenesis; Neurospora crassa ; repeat-induced point mutation; translesion polymerases

    • Abstract

       

      Pol ζ, Pol η, Pol ι, Pol κ and Rev1 are specialized DNA polymerases that are able to synthesize DNA across a damaged template. DNA synthesis by such translesion polymerases can be mutagenic due to the miscoding nature of most damaged nucleotides. In fact, many mutational and hypermutational processes in systems ranging from yeast to mammals have been traced to the activity of such polymerases. We show however, that the translesion polymerases are dispensable for repeat-induced point mutation (RIP) inNeurospora crassa. Additionally, we demonstrate that theupr-1 gene, which encodes the catalytic subunit of Pol ζ, is a highly polymorphic locus in Neurospora.

    • Author Affiliations

       

      Ranjan Tamuli1 C Ravindran1 Durgadas P Kasbekar1

      1. Centre for Cellular and Molecular Biology, Hyderabad - 500 007, India

    • Dates

       
      Published
      December 2006
      Manuscript received
      25 July 2006
      Accepted
      3 September 2006

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      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


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