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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/031/05/0543-0550

    • Keywords

       

      fMRI; hypothyroid; hyperthyroid; motor task

    • Abstract

       

      Thyroid dysfunction is associated with attention deficit and impairment of the motor system (muscle weakness and fatigue). This paper investigates possible motor function deficit in thyroid patients, compared to the controls. Functional MRI studies (fMRI) were carried out in five hypo and five hyperthyroid patients and six healthy volunteers. Whole brain imaging was performed using echo planar imaging (EPI) technique, on a 1.5T whole body MR system (Siemens Magnetom Vision). The task paradigm consisted of 8 cycles of active and reference phases of 6 measurements each, with right index finger tapping at a rate of 120 taps/min. Post-processing was performed using statistical parametric mapping on a voxel-by-voxel basis using SPM99. Clusters of activation were found in the contralateral hemisphere in primary somatomotor area (M1), supplementary motor area (SMA), somatosensory, auditory receptive and integration areas, inferior temporal lobe, thalamus and cerebellum. Increased clusters of activation were observed in M1 in thyroid subjects as compared to controls and with bilateral activation of the primary motor cortex in two hyperthyroid patients. The results are explained in terms of increased functional demands in thyroid patients compared to volunteers for the execution of the same task.

    • Author Affiliations

       

      S Khushu1 S Senthil Kumaran1 T Sekhri2 R P Tripathi1 P C Jain3 V Jain1

      1. NMR Research Centre, Institute of Nuclear Medicine and Allied sciences, Brig. S K Majumdar Road, Delhi - 110 054, India
      2. Thyroid Research Centre, Institute of Nuclear Medicine and Allied sciences, Brig. S K Majumdar Road, Delhi - 110 054, India
      3. Department of Physics and Astrophysics, University of Delhi, Delhi - 110 007, India

    • Dates

       
      Published
      December 2006
      Manuscript received
      17 July 2006
      Accepted
      25 August 2006

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    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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