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    • Mechanism of recycling of post-termination ribosomal complexes in eubacteria: A new role of initiation factor 3

      Anuradha Seshadri Umesh Varshney

      Review Volume 31 Issue 2 June 2006 pp 281-289

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/031/02/0281-0289

    • Keywords

       

      EFG; IF3; post-TC; protein synthesis; RF; specific interactions

    • Abstract

       

      Ribosome recycling is a process which dissociates the post-termination complexes (post-TC) consisting of mRNA-bound ribosomes harbouring deacylated tRNA(s). Ribosome recycling factor (RRF), and elongation factor G (EFG) participate in this crucial process to free the ribosomal subunits for a new round of translation. We discuss the overall pathway of ribosome recycling in eubacteria with especial reference to the important role of the initiation factor 3 (IF3) in this process. Depending on the step(s) at which IF3 function is implicated, three models have been proposed. In model 1, RRF and EFG dissociate the post-TCs into the 50S and 30S subunits, mRNAand tRNA(s). In this model, IF3, which binds to the 30S subunit, merely keeps the dissociated subunits apart by its anti-association activity. In model 2, RRF and EFG separate the 50S subunit from the post-TC. IF3 then dissociates the remaining complex of mRNA, tRNA and the 30S subunit, and keeps the ribosomal subunits apart from each other. However, in model 3, both the genetic and biochemical evidence support a more active role for IF3 even at the step of dissociation of the post-TC by RRF and EFG into the 50S and 30S subunits.

    • Author Affiliations

       

      Anuradha Seshadri1 Umesh Varshney1

      1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560 012, India

    • Dates

       
      Published
      June 2006
      Manuscript received
      28 February 2006
      Accepted
      21 April 2006

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