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      https://www.ias.ac.in/article/fulltext/jbsc/030/04/0491-0497

    • Keywords

       

      Intraspinal; morphine; nimodipine; tail flick latency

    • Abstract

       

      Calcium plays an important role in the pathophysiology of pain. A number of studies have investigated the effect of L-type calcium channel blockers on the analgesic response of morphine. However, the results are conflicting. In the present study, the antinociceptive effect of morphine (2–5 Μg) and nimodipine (1 Μg) co-administered intraspinally in mice was observed using the tail flick test. It was compared to the analgesic effect of these drugs (morphine — 250 Μg subcutaneously; nimodipine — 100 Μg intraperitoneally) after systemic administration. Nimodipine is highly lipophilic and readily crosses the blood brain barrier. Addition of nimodipine to morphine potentiated the analgesic response of the latter when administered through the intraspinal route but not when administered through systemic route. It may be due to direct inhibitory effect of morphine and nimodipine on neurons of superficial laminae of the spinal cord after binding to Μ-opioid receptors and L-type calcium channels respectively.

    • Author Affiliations

       

      Dilip Verma1 Subrata Basu Ray1 Ishan Patro1 2 Shashi Wadhwa1

      1. Department of Anatomy, All India Institute of Medical Sciences, New Delhi - 110 029, India
      2. Neuroscience Centre, Jiwaji University, Gwalior - 474 011, India
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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