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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/030/01/0093-0102

    • Keywords

       

      Gene-environment interactions; low penetrance genes; multiple primary cancers; SNP

    • Abstract

       

      Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.

    • Author Affiliations

       

      Ashwin Kotnis1 Rajiv Sarin1 2 Rita Mulherkar1

      1. Genetic Engineering, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai - 410 208, India
      2. Tata Memorial Hospital, Parel, Mumbai - 400 012, India
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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