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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/028/06/0683-0690

    • Keywords

       

      Analysis; experiments; peptide neighbour preferences

    • Abstract

       

      Two possibilities exist for the evolution of individual enzymes/proteins from a milieu of amino acids, one based on preference and selectivity and the other on the basis of random events. Logic is overwhelmingly in favour of the former. By protein data base analysis and experiments, we have provided data to show the manifestation of two types of preferences, namely, the choice of the neighbour and its acceptance from the amino end (left) or the carboxyl end (right). The study tends to show that if the 20 proteinous amino acids were made to combine in water, the resulting profile would be nonrandom. Such selectivity could be a factor in protein evolution.

    • Author Affiliations

       

      Subramania Ranganathan1 2 Dinabandhu Kundu3 S D Vudayagiri1

      1. Discovery Laboratory, Indian Institute of Chemical Technology, Hyderabad - 500 007, India
      2. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore - 560 064, India
      3. Department of Chemistry, Scottish Church College, Kolkota - 700 006, India

    • Dates

       
      Published
      December 2003
      Manuscript received
      9 July 2003
      Accepted
      16 August 2003

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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