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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/028/03/0349-0358

    • Keywords

       

      Antioxidant; baculovirus; host-pathogen; eIF2α-kinase; P35; PKR

    • Abstract

       

      Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.

    • Author Affiliations

       

      Seyed E Hasnain1 2 3 Rasheeda Begum4 K V A Ramaiah5 Sudhir Sahdev1 E M Shajil4 Tarvinder K Taneja2 Manjari Mohan2 M Athar6 Nand K Sah2 M Krishnaveni1

      1. Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad - 500 076, India
      2. Eukaryotic Gene Expression Lab, National Institute of Immunology, New Delhi - 110 076, India
      3. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore - 560 064, India
      4. Department of Biochemistry, M S University of Baroda, Vadodara - 390 002, India
      5. Department of Biochemistry, University of Hyderabad, Hyderabad - 500 046, India
      6. Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi - 110 062, India

    • Dates

       
      Published
      April 2003

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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