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    • Keywords


      Antioxidant; baculovirus; host-pathogen; eIF2α-kinase; P35; PKR

    • Abstract


      Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.

    • Author Affiliations


      Seyed E Hasnain1 2 3 Rasheeda Begum4 K V A Ramaiah5 Sudhir Sahdev1 E M Shajil4 Tarvinder K Taneja2 Manjari Mohan2 M Athar6 Nand K Sah2 M Krishnaveni1

      1. Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad - 500 076, India
      2. Eukaryotic Gene Expression Lab, National Institute of Immunology, New Delhi - 110 076, India
      3. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore - 560 064, India
      4. Department of Biochemistry, M S University of Baroda, Vadodara - 390 002, India
      5. Department of Biochemistry, University of Hyderabad, Hyderabad - 500 046, India
      6. Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi - 110 062, India
    • Dates

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