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    • Regulatory mechanisms of viral hepatitis B and C

      G Waris A Siddiqui

      Articles Volume 28 Issue 3 April 2003 pp 311-321

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/028/03/0311-0321

    • Keywords

       

      ER stress; hepatitis B virus; hepatitis C virus; NF-κB; oxidative stress; STAT-3

    • Abstract

       

      Of all the hepatitis viruses, only the hepatitis B virus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. In this review, we discuss how these two biologically diverse viruses use common pathways to induce oxidative stress and activation of key transcription factors, known to be involved in inflammatory processes in cells. Activation of NF-κB and STAT-3 most likely contribute to the progression of viral infections to chronic hepatitis and liver oncogenesis associated with HBV and HCV infections. In this review, we focus on the mechanisms of action of HBx and HCV NS5A proteins in inducing intracellular events associated with the viral infections.

    • Author Affiliations

       

      G Waris1 A Siddiqui1

      1. Department of Microbiology, Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 E, 9th Ave, Denver, Colorado - 80262, USA

    • Dates

       
      Published
      April 2003

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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      Posted on July 25, 2019

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