• Regulatory mechanisms of viral hepatitis B and C

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      https://www.ias.ac.in/article/fulltext/jbsc/028/03/0311-0321

    • Keywords

       

      ER stress; hepatitis B virus; hepatitis C virus; NF-κB; oxidative stress; STAT-3

    • Abstract

       

      Of all the hepatitis viruses, only the hepatitis B virus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. In this review, we discuss how these two biologically diverse viruses use common pathways to induce oxidative stress and activation of key transcription factors, known to be involved in inflammatory processes in cells. Activation of NF-κB and STAT-3 most likely contribute to the progression of viral infections to chronic hepatitis and liver oncogenesis associated with HBV and HCV infections. In this review, we focus on the mechanisms of action of HBx and HCV NS5A proteins in inducing intracellular events associated with the viral infections.

    • Author Affiliations

       

      G Waris1 A Siddiqui1

      1. Department of Microbiology, Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 E, 9th Ave, Denver, Colorado - 80262, USA
    • Dates

       
  • Journal of Biosciences | News

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