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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/028/02/0181-0188

    • Keywords

       

      Astrocytoma; glioblastoma multiforme; immunohistochemistry; neurotrophin receptors; Trk A; Trk B

    • Abstract

       

      Neurotrophins and their receptors of the Trk family play a critical role in proliferation, differentiation and survival of the developing neurons. There are reports on their expression in neoplasms too, namely, the primitive neuroectodermal tumours of childhood, and in adult astrocytic gliomas. The involvement of Trk receptors in tumour pathogenesis, if any, is not known. With this end in view, the present study has examined 10 tumour biopsy samples (identified as astrocytoma, pilocytic astrocytoma and glioblastoma) and peritumoral brain tissue of adult patients, for the presence of Trk A and Trk B receptors, by immunohistochemistry. The nature of the tumour samples was also confirmed by their immunoreactivity (IR) to glial fibrillary acidic protein. In the peritumoral brain tissue, only neurons showed IR for Trk A and Trk B. On the contrary, in the tumour sections, the IR to both receptors was localized in the vast majority of glia and capillary endothelium. There was an obvious pattern of IR in these gliomas: high levels of IR were present in the low-grade (type I and II) astrocytoma; whereas in the advanced malignant forms (WHO grade IV giant cell glioblastoma and glio-blastoma multiforme) the IR was very weak. These findings suggest that Trk A and Trk B are involved in tumour pathogenesis, especially in the early stage, and may respond to signals that elicit glial proliferation, and thus contribute to progression towards malignancy.

    • Author Affiliations

       

      Shashi Wadhwa1 Tapas C Nag1 Anupam Jindal1 2 Rahul Kushwaha1 2 Ashok K Mahapatra1 2 Chitra Sarkar1 3

      1. Department of Anatomy, All India Institute of Medical Sciences, New Delhi - 110 029, India
      2. Department of Neurosurgery, CN Center, All India Institute of Medical Sciences, New Delhi - 110 029, India
      3. Department of Pathology, All India Institute of Medical Sciences, New Delhi - 110 029, India

    • Dates

       
      Published
      March 2003
      Manuscript received
      15 July 2002
      Accepted
      21 January 2003

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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