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    • Keywords


      Cytotoxicity; reactive nitrogen species; reactive oxygen species; yellow sand

    • Abstract


      The present study was carried out to observe the cytotoxicity of yellow sand in comparison with silica and titanium dioxide in a rat alveolar type II cell line (RLE-6TN). Yellow sand (China Loess) was obtained from the loess layer in the Gunsu Province of China. The mean particle diameter of yellow sand was about 0003 ± 0.001 mm. Major elements of yellow sand were Si(27.7 ± 0.6%), Al(6.01± 0.17%), and Ca(5.83 ± 0.23%) in that order. Silica and yellow sand significantly decreased cell viability and increased [Ca2+]i. All three particles increased the generation of H2O2. TiO2 did not change Fenton activity, while silica induced a slight increase of Fenton activity. In contrast, yellow sand induced a significant increase of Fenton activity. Silica, yellow sand and TiO2 induced significant nitrite formations in RLE-6TN cells. Silica showed the highest increase in nitrite formation, while yellow sand induced the least formation of nitrite. Silica and yellow sand increased the release of TNF-α. Based on these results, we suggest that yellow sand can induce cytotoxicity in RLE-6TN cells and reactive oxygen species, Fenton activity and reactive nitrogen species might be involved in this toxicity.

    • Author Affiliations


      Y H Kim1 K S Kim1 N J Kwak1 K H Lee1 2 S A Kweon3 Y Lim1 4

      1. Research Institute of New Drug Development, The Catholic University of Korea, Seoul, Korea
      2. Department of Pharmacology, The Catholic University of Korea, Seoul, Korea
      3. Environment Technology Center, NIER, The Catholic University of Korea, Seoul, Korea
      4. Department of Occupational and Environmental Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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