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    • Keywords


      Gliomas; mutations; p53; single strand conformation polymorphism

    • Abstract


      Alterations in the tumour suppressorp53 gene are among the most common defects seen in a variety of human cancers. In order to study the significance of thep53 gene in the genesis and development of human glioma from Indian patients, we checked 44 untreated primary gliomas for mutations in exons 5–9 of thep53 gene by PCR-SSCP and DNA sequencing. Sequencing analysis revealed six missense mutations. The incidence of p53 mutations was 13⋅6% (6 of 44). All the six mutations were found to be located in the central core domain of p53, which carries the sequence-specific DNA-binding domain. These results suggest a rather low incidence but a definite involvement of p53 mutations in the gliomas of Indian patients.

    • Author Affiliations


      Pornima Phatak1 S Kalai Selvi1 T Divya1 2 A S Hegde1 2 Sridevi Hegde1 2 Kumaravel Somasundaram1

      1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560 012, India
      2. Manipal Institute for Neurological Disorders, Manipal Hospital, Airport Road, Bangalore - 560 017, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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