1. Home
    2. Journals
    3. Journal of Biosciences
    4. Volume 27
    5. Issue 1

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/027/01/0053-0065

    • Keywords

       

      DNA hairpins; DNA structure; slipped strand DNA; triplet repeat disease; triplet repeats

    • Abstract

       

      Fourteen genetic neurodegenerative diseases and three fragile sites have been associated with the expansion of (CTG)n•(CAG)n, (CGG)n•(CCG)n, or (GAA)n•(TTC)n repeat tracts. Different models have been proposed for the expansion of triplet repeats, most of which presume the formation of alternative DNA structures in repeat tracts. One of the most likely structures, slipped strand DNA, may stably and reproducibly form within triplet repeat sequences. The propensity to form slipped strand DNA is proportional to the length and homogeneity of the repeat tract. The remarkable stability of slipped strand DNA may, in part, be due to loop-loop interactions facilitated by the sequence complementarity of the loops and the dynamic structure of three-way junctions formed at the loop-outs.

    • Author Affiliations

       

      Richard R Sinden1 Vladimir N Potaman1 Elena A Oussatcheva1 Christopher E Pearson1 2 Yuri L Lyubchenko1 3 Luda S Shlyakhtenko1 3

      1. Laboratory of DNA Structure and Mutagenesis, Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Sciences Center, 2121 West Holcombe Blvd., Houston, TX - 77030-3303, USA
      2. Department of Genetics, Hospital for Sick Children, 555 University Avenue, Elm Wing, Rm. 11-135, Toronto, Ontario - M5G 1X8, Canada
      3. Departments of Biology and Microbiology, Arizona State University, Tempe, AZ - 85287-2701, USA

    • Dates

       
      Published
      February 2002

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
      <

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2022-2023 Indian Academy of Sciences, Bengaluru.

Contact | Site index