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    • Keywords


      DNA hairpins; DNA structure; slipped strand DNA; triplet repeat disease; triplet repeats

    • Abstract


      Fourteen genetic neurodegenerative diseases and three fragile sites have been associated with the expansion of (CTG)n•(CAG)n, (CGG)n•(CCG)n, or (GAA)n•(TTC)n repeat tracts. Different models have been proposed for the expansion of triplet repeats, most of which presume the formation of alternative DNA structures in repeat tracts. One of the most likely structures, slipped strand DNA, may stably and reproducibly form within triplet repeat sequences. The propensity to form slipped strand DNA is proportional to the length and homogeneity of the repeat tract. The remarkable stability of slipped strand DNA may, in part, be due to loop-loop interactions facilitated by the sequence complementarity of the loops and the dynamic structure of three-way junctions formed at the loop-outs.

    • Author Affiliations


      Richard R Sinden1 Vladimir N Potaman1 Elena A Oussatcheva1 Christopher E Pearson1 2 Yuri L Lyubchenko1 3 Luda S Shlyakhtenko1 3

      1. Laboratory of DNA Structure and Mutagenesis, Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Sciences Center, 2121 West Holcombe Blvd., Houston, TX - 77030-3303, USA
      2. Department of Genetics, Hospital for Sick Children, 555 University Avenue, Elm Wing, Rm. 11-135, Toronto, Ontario - M5G 1X8, Canada
      3. Departments of Biology and Microbiology, Arizona State University, Tempe, AZ - 85287-2701, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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