• Molecular approaches to contraceptive development

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/026/04/0407-0419

    • Keywords

       

      Molecular modelling; non-hormonal contraceptives; non-peptide hormone analogues; transgenic animals

    • Abstract

       

      The next generation of contraceptives will be based on the identification of novel molecules essential for reproductive processes and will rely on the refinement of older as well as newer technologies. Functional analysis of naturally occurring reproductive genetic disorders and creation of mice null for specific genes would greatly assist in the choice of genetic targets for contraceptive development. Structure-based design of drugs as exemplified by the preparation of an orally active non-peptide gonadotropin releasing hormone (GnRH) would revolutionize drug formulation and delivery for a peptide analogue. This review examines some of the molecular targets that may change contraceptive choices in the future.

    • Author Affiliations

       

      Usha Natraj1

      1. Institute for Research in Reproduction, JM Street, Parel, Mumbai - 400 012, India
    • Dates

       
  • Journal of Biosciences | News

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