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    • Orally active insulin mimics: where do we stand now?

      M Balasubramanyam V Mohan

      Review Volume 26 Issue 3 September 2001 pp 383-390

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/026/03/0383-0390

    • Keywords

       

      Insulin mimetic; insulin receptor tyrosine kinase; PI 3-kinase; vanadium

    • Abstract

       

      The war against diabetes through the development of new drugs is an ongoing continuous process to counter the alarming global increase in the prevalence of diabetes and its complications, particularly in developing countries like India. Unfortunately, the speed with which our knowledge of diabetes and its effects is expanding is not matched by the availability of new drugs. Following the identification of the insulin receptor (IR), its intrinsic kinase activity and molecular cloning, many studies have looked at IR as an ideal drug target. This review summarizes in brief the latest advancements in this field with particular reference to the current situation in respect of the development of orally active insulin mimetics in the treatment of type 2 diabetes.

    • Author Affiliations

       

      M Balasubramanyam1 V Mohan1

      1. Madras Diabetes Research Foundation (MDRF), 35 Conran Smith Road, Gopalapuram, Chennai - 600 086, India

    • Dates

       
      Published
      September 2001
      Manuscript received
      8 February 2001
      Accepted
      4 May 2001

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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