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    • Dynamical complexity and temporal plasticity in pancreatic 𝛽-cells

      Richard Bertram Arthur Sherman

      Review article Volume 25 Issue 2 June 2000 pp 197-209

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/025/02/0197-0209

    • Keywords

       

      Bursting; coupled oscillators; mathematical model

    • Abstract

       

      We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic 𝛽-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.

    • Author Affiliations

       

      Richard Bertram1 2 Arthur Sherman1 2

      1. Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
      2. Mathatical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

    • Dates

       
      Published
      June 2000
      Manuscript received
      27 March 2000
      Accepted
      1 May 2000

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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