• Dynamical complexity and temporal plasticity in pancreatic 𝛽-cells

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    • Keywords


      Bursting; coupled oscillators; mathematical model

    • Abstract


      We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic 𝛽-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.

    • Author Affiliations


      Richard Bertram1 2 Arthur Sherman1 2

      1. Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
      2. Mathatical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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