• Analysis of BRCA1 involvement in breast cancer in Indian women

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      https://www.ias.ac.in/article/fulltext/jbsc/025/01/0019-0023

    • Keywords

       

      BRCA1 ; breast cancer; microsatellite polymorphisms; tumour suppressive function

    • Abstract

       

      The involvement of the familial breast-ovarian cancer gene (BRCA1) in the molecular pathogenesis of breast cancer among Indian women is unknown. We have used a set of microsatellite polymorphisms to examine the frequency of allele loss at the BRCA1 region on chromosome 17q21, in a panel of 80 human breast tumours. Tumour and blood leukocyte/normal tissue DNA from a series of 80 patients with primary breast cancer was screened by PCR-amplified microsatellite length polymorphisms to detect deletions at three polymorphic BRCA1 loci. PCR-allelotype was valuable in examining allele losses from archival and small tumour samples. Loss of alleles at BRCA1 in the patient set, confirmed a noteworthy role of this gene in the molecular pathogenesis of breast cancer and was in accordance with its well-documented tumour suppressive function.

    • Author Affiliations

       

      P H Pestonjamasp1 I Mittra1 2

      1. Division of Laboratory Medicine, Tata Memorial Hospital, Ernest Borges Road, Parel, Mumbai - 400 012, India
      2. Department of Surgery, Tata Memorial Hospital, Ernest Borges Road, Parel, Mumbai - 400 012, India
    • Dates

       
  • Journal of Biosciences | News

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