• Relationship between power law coefficients and major blood constituents affecting the whole blood viscosity

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      https://www.ias.ac.in/article/fulltext/jbsc/024/03/0329-0337

    • Keywords

       

      Cerebrovascular accidents (CVA); blood viscosity; power law; haematocrit; fibrinogen; cholesterol

    • Abstract

       

      The present work concerns a quantitative analysis of parameters that affect apparent blood viscosity at different low shear rates, i.e, between 1 s−1 and, 100 s−1. Viscosity profile of a large number of blood samples from thromboembolic stroke cases and age and sex matched healthy controls were studied which confirmed non-Newtonian power law behaviour of blood. The power law coefficients,n andk, which are unique to each blood sample, were related with blood viscosity parameters in the form of a mathematical equation by performing non-linear regression analysis. It was possible to calculaten andk of power law model by supplying the values of major blood constituents in the equation obtained for stroke and controls. The calculation ofn andk of a blood sample using the equation obtained, provided a quick information on its apparent viscosity values at any given shear rate without viscometry. The calculated and the experimental viscosity were found in good agreement within a permissible error range. The relation obtained between power law coefficients and major blood constituents in the present investigation would give a quantification of different blood viscosity parameters contributing to the resistance to flow of blood. Such an analysis may be considered as a scientific basis for the study of blood fluidity in different disease conditions.

    • Author Affiliations

       

      Mohammad A Hussain1 Subir Kar1 Ram R Puniyani1

      1. School of Biomedical Engineering, Indian Institute of Technology Bombay, Mumbai - 400 076, India
    • Dates

       
  • Journal of Biosciences | News

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