• Genome analysis for nucleotide interactions in fully sequenced genomes of selective prokaryotes

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    • Keywords


      Genome; frequency; dicon; codon; dinucleotide; chaos; randomness

    • Abstract


      Fully sequenced prokaryotic genomes ofEscherichia coli, Haemophilus influenzae andMethanococcus janaschii were subjected .to genome analysis for nucleotide interactions. The analysis was restricted to inter-nucleotide relations like two nucleotides in a dinucleotide, three nucleotides in a codon and two codons in a dicon. This relational analysis was carried out in C language and was compiled on a C++ compiler. The relational analysis showed a preferential dinucleotide frequency (the observed frequencies of AA and TT were higher than the expected frequency and the observed frequencies of CC and GG). From codon frequency distribution analysis, sub-codonic elements have been noticed, exerting that the first one or first two nucleotide may reasonably determine the next nucleotide(s) in a codon. The analysis further reveals the existence of short-range randomness or chaotic behaviour in prokaryotic genomes, which might be a forerunner for the origin of introns in eukaryotes, besides being involved in a regulatory role.

    • Author Affiliations


      B V L S Prasaot1 2 Mohan C Vemuri1

      1. School of Life Sciences, University of Hyderabad, Hyderabad - 500 046, India
      2. Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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