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    • Keywords


      Melanosomal proteins; tyrosinase related proteins; tyrosinase activation and inhibition

    • Abstract


      A single polypeptide protein (MP 66) of molecular weight 66 kDa purified to homogeneity from melanosomes of normal human skin epidermal melanocytes, was partially characterized. The isoelectric point of MP 66 is in the range of 7.3 to 7.6. This protein, which was shown to inhibit partially purified human skin tyrosinase activity at pH 6.8, also inhibits murine tyrosinase at pH 6.8. However, at pH 5.0, it stimulates murine tyrosinase activity. The physiological implications of these results are discussed.

    • Author Affiliations


      Badisa Ramesh Babu1 Ganeshrao Diwakar2 Abburi Ramaiah1 Tasneem Fatma3

      1. Department of Biophysics, All India Institute of Medical Sciences, New Delhi - 110 029, India
      2. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi - 110 029, India
      3. Centre for Biosciences, Lamia Millia Islamia, New Delhi - 110 025, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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