• Mechanism of initiation of yeast mitochondrial DNA replication: Role of RNA polymerase

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    • Keywords


      RNA polymerase; yeast; mitochondria

    • Abstract


      Yeast mitochondrial RNA polymerase was purified and resolved into 2 distinct fractions. Peak A was found to be nonspecific and exhibited characteristics of the core polymerase, whereas peak B exhibited characteristics of the holoenzyme.In vitro replication assays were carried out, using the peak B enzyme, the clonedori sequences and other DNA templates. It was found thatori 2 was the most efficient template for RNA polymerase primed DNA synthesis, as compared to all the other templates studied.

    • Author Affiliations


      Suzanne D’souza1 K Pasupathy1

      1. Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay - 400 085, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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