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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/022/01/0111-0116

    • Keywords

       

      Leprosy ; Mycobacterium leprae 35 kDa antigen ; skin scrapings ; skin biopsies

    • Abstract

       

      Skin scrapings obtained from the lesions of leprosy patients of all types showed 96 % positivity to the serum antibody competition test using monoclonal antibody (ML04)to 35 kDa antigen ofMycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from lepromatous patients were noted to release IgG antibodies toM. leprae with a peak antibody response at 48 h. The significance of this local antibody response toM. leprae in skin has been discussed for its possible use in diagnosing early leprosy.

    • Author Affiliations

       

      Om Parkash1 M K Beuria1 B K Girdhar1 K Katoch1 U Sengupta1

      1. Central Jalma Institute for Leprosy, Taj Ganj, Agra - 282001, India
    • Dates

       
  • Journal of Biosciences | News

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