• Alignment and phylogenetic analysis of type II DNA topoisomerases

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      https://www.ias.ac.in/article/fulltext/jbsc/021/05/0613-0629

    • Keywords

       

      Type II DNA topoisomerases ; DNA gyrase ; multiple alignment ; phylogenetic trees

    • Abstract

       

      DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation. This analysis shows the distinct evolutionary relatedness of type II DNA topoisomerases. A striking feature is the absence of a contiguous stretch of about 160 amino acids in one of the subunits of prokaryotic type II enzymes, which might have important implications to their structure and function.

    • Author Affiliations

       

      K Madhusudan1 V Nagaraja1

      1. Centre for Genetic Engineering, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

       
  • Journal of Biosciences | News

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