• Alignment and phylogenetic analysis of type II DNA topoisomerases

    • Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      Type II DNA topoisomerases ; DNA gyrase ; multiple alignment ; phylogenetic trees

    • Abstract


      DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation. This analysis shows the distinct evolutionary relatedness of type II DNA topoisomerases. A striking feature is the absence of a contiguous stretch of about 160 amino acids in one of the subunits of prokaryotic type II enzymes, which might have important implications to their structure and function.

    • Author Affiliations


      K Madhusudan1 V Nagaraja1

      1. Centre for Genetic Engineering, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.