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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/020/03/0453-0460

    • Keywords

       

      Malaria; IgA; enzyme immuno-assay; Plasmodium falciparum peptide antigens

    • Abstract

       

      Blood samples collected from individuals belonging to an endemic area in Uttar Pradesh, were tested for plasmodial antigen specific immunoglobulin A (IgA) by enzyme immuno assay using soluble extract ofPlasmodium falciparum from culture. Among 773 (20.18%,P < 0.0001) samples 156 sera demonstrated a detectable seropositivity for antigen specific IgA. IgA levels were higher among individuals who experienced repeated attacks of malaria compared to acute infected patients. Among seropositive individuals the IgA titers were found increased with the age. Immunoglobulin isolated from sera having high level of IgA showed growth inhibitory effect inPlasmodium falciparum in vitro. A group of sera with high IgA antibody againstPlasmodium falciparum crude antigen showed seronegativity with specific peptides. Statistically, no positive or negative correlations were observed between antigen specific IgG and IgA. However, there was a tendency towards negative correlation between IgA and IgM. Mechanisms for the parasite specific IgA production remain to be established.

    • Author Affiliations

       

      Sukla Biswas1 Queen B Saxena1 Arati Roy1 Lalitha Kabilan1

      1. Malaria Research Centre, 22 Sham Nath Marg, Delhi - 110 054, India
    • Dates

       
  • Journal of Biosciences | News

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