• Mutations in tumour suppressor genes,l(2)gl andl(2)gd, alter the expression ofwingless inDrosophila

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    • Keywords


      Segment polarity genes; wingless ; tumour suppressor genes; 1l(2) gl; l(2) gd

    • Abstract


      To understand the roles of two well known tumour suppressor genes.l(2)gl andl(2)gd in normal imaginal disc development inDrosophila, we have initiated a study to examine effect of mulations of these genes on the expression of genes involved in the patterning of the imaginal discs. In this study we show that the expression ofwingless, theDrosophila orthologue of the mammalian oncogeneWnt, is affected in the imaginal discs ofl(2)gl4 andl(2)gd1 mutant individuals. In the tumourous wing imaginal discs froml(2)gl mutant larvae, the pattern ofwingless expression was progressively disrupted with an increase in the area of expression, Tumourous wing imaginal discs froml(2)gd homozygous individuals exhibited progressive broadening and extension of the wingless expressing domains. We suggest thatl(2)gl andl(2)gd might be involved in regulating post embryonic expression ofWingless.

    • Author Affiliations


      Ashim Mukherjee1 J K Roy1

      1. Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi - 221 005, India
    • Dates

  • Journal of Biosciences | News

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