• Age-related prevalence of antibodies to infective larvae ofWuchereria bancrofti in normal individuals from a filaria-endemic region

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    • Keywords

       

      Infective-larvae; Wuchereria bancrofti ; antibody isotypes; age dependency; filariasis; endemic normals

    • Abstract

       

      Antibody isotypic levels (IgM, IgE and IgG subclasses) to infective larvae (L3) ofWuchereria bancrofti were measured in 104 normal individuals from a filaria-endemic region in Orissa. The titres of antibodies were considerably higher in adults (n = 25, 25.1± 3.8 year) than in children (n = 52, 7.1 ± 2.1 year). Young children (n = 14) less than four years were seronegative to all isotypes other than IgM, the sero-conversion to which was achieved in the children (n=15) by the age of 7.5±1.2 years. The prevalence of other isotypes increased with age and reached a maximum in early adulthood (18.6 ±1.6 years), which persisted in older adults (> 30 years). However, the increase in IgG3 prevalence with age was less marked. IgG2 was detected only after 10 years of age. Compared to the high prevalence (100%) of IgM, IgE, IgG1, and IgG2, in adults. IgG3 and IgG4 prevalences were low, 35% and 28% respectively. IgA level to L3 antigen was found to be extremely low even in adults. These data indicate that the prevalence of L3 antibodies was different for different isotypes and the acquisition of antibody response essentially followed an age dependent pattern.

    • Author Affiliations

       

      M K Beuria1 M Bal1 A P Dash1 Manoj K Das1

      1. Parasite Immunology Division, Regional Medical Research Centre, Nandankanan Road, Bhubaneswar - 751 016, India
    • Dates

       
  • Journal of Biosciences | News

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