• Antigenicity of filarial superoxide dismutase in human bancroftian filariasis

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      https://www.ias.ac.in/article/fulltext/jbsc/020/02/0157-0166

    • Keywords

       

      Filariasis; superoxide dismutase; Wuchereria bancrofti ; Setaria digitata

    • Abstract

       

      Superoxide dismutase activity was measured in different stages of growth of filarial parasites (human and cattle). The activity was almost undetected or very low in microfilarial stage but in adult worms, the enzyme activity was high. The enzyme was characterized to be a Cu/Zn superoxide dismutase. Most of the enzyme activity was associated with a detergent extractable fraction of adult (Setaria) parasite. The enzyme was also detected in thein vitro released products of adult worms. The superoxide dismutase activity was completely inhibited with IgG antibody from chronic filarial patients in contrast to IgG from normal people. Filarial patients particularly have high IgG and IgM antibody levels to purified enzyme. However, individuals from non-filarial regions of Orissa are sero-negative for superoxide dismutase antibodies. Antibody response to superoxide dismutase could thus be used for filarial diagnosis.

    • Author Affiliations

       

      Madhusmita Bal1 Manoj K Das1

      1. Parasite Immunology Division, Regional Medical Research Centre, Nandankanan Road, Bhubaneswar - 751 016, India
    • Dates

       
  • Journal of Biosciences | News

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