• Nondegradative pisatin-resistance inDictyostelium discoideum, Neurospora crassa andNectria haematococca: Similarities and differences

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    • Keywords


      Phytoalexin tolerance; sterol mutants; spore walls; azasterol A25822B

    • Abstract


      Paradoxically, on pisatin-medium (150 μg/ml) the cellular slime mouldDictyostelium discoideum grows only when plated as spores but not when plated as amoebae. The recent discovery of inducible nondegradativc pisatin resistance in amoebae has allowed us to formulate a model that resolves this paradox. In this model, the germinating amoeba is postulated to acquire a pisatin-resistance phenotype while ensconced within the spore wall. This article reviews the findings on which this model is based and extends it to also account for the differences in pisatin sensitivity phenotype that result from sterol alteration in cellular slime moulds and fungi.

    • Author Affiliations


      Durgadas P Kasbekar1

      1. Centre for Cellular and Molecular Biology, Hyderabad - 500 007, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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