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Polypeptide sequences; correlations; pair preferences; periodicities

The correlation between various amino acid residues (either same or different), along the polypeptide chain have been studied using a large data base. A table of preference values for pairs having strong correlations has been constructed, which can be used to study any sequence and by calculating the weight of these sequences based on these preference values, a rough distinction between a “natural” and a “random” sequence can be made, One can further comment on the evolutionary status of proteins based on these weights.

Meeta Rani¹ Chanchal K Mitra¹

1. School of Life Sciences, University of Hyderabad, Hyderabad - 500 134, India

Published

June 1994

Manuscript received

10 August 1993

Manuscript revised

25 February 1994