• Enhanced antibody response to a detergent-soluble antigen in human filariasis after treatment with diethylcarbamazine

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      https://www.ias.ac.in/article/fulltext/jbsc/019/02/0201-0206

    • Keywords

       

      Lymphatic filariasis; chemotherapy; immunity; purified antigen

    • Abstract

       

      An antigen fraction has been isolated from the water insoluble component of cattle filarial parasiteSetaria digitata by detergent NP-40 solubilization, precipitation with ammonium sulphate and fractionation on sephadex G-100. Immunoglobulin G response to the isolated antigenic fraction was selectively suppressed in asymptomatic microfilaraemic people in comparison to the amicrofilaraemic groups of endemic normals and chronic patients. However, treating microfilaraemic people with diethylcarbamazine enhanced the antibody levels by 10-fold. These results suggest that active infection suppresses the response induced by the isolated antigenic fraction which is elevated after clearance of microfilariae.

    • Author Affiliations

       

      A K Praharaj1 2 Manoj K Das1

      1. Division of Parasite Immunology, Regional Medical Research Centre (ICMR), Nandankanan Road, Bhubaneswar - 751 016, India
      2. Command Pathology Laboratory, West Command, Delhi Cantonment, New Delhi - 110 010, India
    • Dates

       
  • Journal of Biosciences | News

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      Posted on July 25, 2019

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