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    • Keywords


      Atrial septal defect; cardiac hypertrophy; c-myc; mysoin heavy chain (MHC); myosin light chain 2; tetralogy of Fallot; TPA

    • Abstract


      A regulatory interdependence of expression of proto-oncogenes and muscle specific genes observed in smooth muscle was examined in cardiac muscle during normal development and hypertrophy both in rats and humans. During normal development in rats, myosin light chain 2 expression is very low at prenatal stages, while c-fos expression starts from the early stages of embryonic development. In aorta constricted rats c-fos induction occurs within 30 min whereas myosin light chain 2 expression is sufficiently high only after 3 or 4 days of post operative period. In the case of humans, the expression of myosin light chain 2 as well as c-fos occurs at high levels during embryonic development. Similar results were obtained with tissue samples obtained from patients with cardiac abnormalities. Induction of the c-fos gene in cultured myocytes by 12-O-tetradeeanoylphorbol 13-acetate has no influence on the expression of myosin light chain 2. These studies were extended with studies on c-myc and Β-myosin heavy chain gene expression which revealed a similar pattern of expression as that of c-fos and myosin light chain 2. These results have indicated that the expression of proto-oncogenes in cardiac muscle may be independently regulated from the expression of muscle specific genes.

    • Author Affiliations


      G Jegadeesh Babu1 N Selvamurugan1 C Kartha1 2 C Rajamanickam1

      1. Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625 021, India
      2. Division of Pathology, Sree China Tirunal Institute for Medical Sciences and Technology, Trivandrum - 69501 1011, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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